Application Notes - International Biopharmaceutical Industry

Current Edition

Current Features

Subsection - Neurodegenerative Diseases

From Depression to Deep-Learning: Leveraging iPSC and AI Platforms for Evidence-Based Depression Treatment

Subsection - Oncology

Essential DMPK Strategies for IND Success

Subsection - Cell and Gene Therapy

When the Gene Editing Guide is the Drug

Application Notes

Benefits of Mass Spectrometry from Process Development to GMP Release of Biomolecules – A Comprehensive CDMO Perspective from Richter BioLogics

In biopharmaceutical production, a thorough understanding of analytical processes and target molecules is essential for ensuring patient safety, as well as maint...

7 October 2025 Application Notes

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Application Notes

Scale-up Evaluation of the DynaDrive S.U.B.s

Part 3: Pilot and Manufacturing Scale Comparison of DynaDrive S.U.B. Capabilities Introduction Commercialisation of a drug is a monumental milestone that h...

7 October 2025 Application Notes

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Application Notes

Use of the aProximateTM ProximalTubule Cell Model for the Evaluation of Safety and RenalAccumulation of Radioconjugates and Large Molecules

The aProximateTM Proximal Tubule Cell (PTC) model offers a cutting-edge platform for the evaluation of drug-induced nephrotoxicity, radioconjugate retention and ...

7 October 2025 Application Notes

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Application Notes

Modelling Retinal Safety: The Era of Predictive In Vitro Toxicology Testing

Bringing a novel therapeutic to market is a complex and costly journey, and toxicity remains a leading reason for failure along the way. Despite remarkable advances ...

17 July 2025 Application Notes | Volume 8 Issue 2

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Application Notes

The Science of Cell Line Development for Biologics: Improving Stability and Yield

Mammalian cell line development is essential to biologics manufacturing, ensuring stable, high-yield expression of therapeutic proteins. With expanding biologics pip...

17 July 2025 Application Notes | Volume 8 Issue 2

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Application Notes

CHO Cell Culture Process Intensification for Enhanced Production of IgG mAbs

Increased demand for higher product yield in biologics requires optimal use of existing manufacturing capacity. Process intensification is one way a facility can mee...

4 April 2025 Application Notes | Volume 8 Issue 1

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Application Notes

Demonstrating Equivalence Between Recombinant Semaglutide APIs

This article presents a quality comparison between the recombinant origin Semaglutide drug substance made by Aurisco and the innovator’s injectable and oral Semaglut...

25 March 2025 Application Notes | Volume 7 Issue 4

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Volume 7 Issue 4

The Benefits of 5,000L Single-use Bioreactors for Biologics Manufacturing

Executive Summary The entry of the 5,000L single-use bioreactor (SUB) into biologics manufacturing is providing an important bridge between small-scale and ...

19 December 2024 Volume 7 Issue 4 | Application Notes

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Volume 7 Issue 3

Next-generation Proximity-based Luminescence Assays & CRISPR/Cas9 Genome Engineering and nanoBRET

Bioluminescence resonance energy transfer (BRET) is a technology often used to probe the proximity of molecules within live cells. BRET assays have many applications...

30 September 2024 Volume 7 Issue 3 | Application Notes

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Volume 7 Issue 3

Meeting Drug Development Challenges: An Insider’s View on CDMO Services for Biologics

As industry leaders and customers from across the globe gathered to discuss the latest trends and challenges in drug development and manufacturing at this year’s BIO...

30 September 2024 Volume 7 Issue 3 | Application Notes

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