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J&J to explore RNA reprogramming with Remix research deal

Dive Brief:

  • Johnson & Johnson is partnering with Remix Therapeutics to develop drugs that are meant to reprogram how RNA is processed, becoming the latest big pharma to expand its research presence in a now fast-growing field.

 

  • Traditionally, drugmakers have targeted proteins to treat disease. Going after RNA, the messenger molecules that translate DNA, has required special technologies that took years to work out. Now newer biotech companies like Remix believe they have the tools to target RNA with chemical pills.

 

  • Under the deal, J&J gets rights to three targets in immunology and oncology. Remix will receive $45 million upfront and is eligible for milestone payments and royalties that could exceed $1 billion if the research succeeds, according to a release Thursday.

Dive Insight:

The science is still in early stages, but companies such as Remix say aiming chemical-based medicines at RNA molecules is the natural next step as drugmakers run out of proteins they can easily target with other methods.

RNA acts as a messenger inside cells, carrying instructions from DNA for protein production. Remix’s technology is designed to “tune” that process to attack the origin of a disease by degrading, boosting or altering RNA. The company aims to do that with small molecule drugs, rather than the nucleic acid therapies used by companies like Alnylam Pharmaceuticals and Ionis Pharmaceuticals.

The promise of using small molecules to target RNA has resulted in a flurry of deals between more established pharmaceutical makers and smaller companies.

Over the last two years, the Massachusetts biotech Arrakis Therapeutics has signed deals with both Roche and Amgen to develop drugs that modify or destroy RNA. In each case, the cash paid upfront was relatively modest, but the agreements hold the potential for “several billion dollars” in future payments if the research pans out.

Roche last year also joined forces with a North Carolina biotech called Ribometrix to target RNA molecules. In 2020, AstraZeneca teamed with Accent Therapeutics and Vertex announced plans to work with Skyhawk Therapeutics. Like the Arrakis deals, the Ribometrix, Accent and Skyhawk agreements are backloaded with big payments dependent on clinical success.

Remix, based in Cambridge Massachusetts, launched in December 2020 with $81 million in financing.