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A Statistical Approach to Improve Compound Screening in Cell Culture Media

The Chinese hamster ovary (CHO) cell line is widely used to produce recombinant proteins due to its high growth capacity and productivity, as well as other cell lines derived later than CHO. Adapting cell culture media for each specific cell line is a key to exploit these features for cost-effective and fast product generation. Eduard Puente-Massaguer et al. at Universitat Autònoma de Barcelona discuss a novel strategy consisting of folding over the Plackett–Burman design, which was used to increase cell growth and trastuzumab production of different CHO cell lines through supplementation with non-animal recombinant compounds.

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