Dive Insight:

Jardiance’s widening potential has followed doctors’ growing understanding of the commonalities between diabetes, heart disease, high blood pressure and kidney disease. Drugs in Jardiance’s class, which treat diabetes by helping the body excrete blood sugar, also appear to reduce pressure on the heart and within the kidneys. Those effects may explain why the drugs, known as SGLT2 inhibitors, are useful for people with renal problems.

Boehringer, working with Lilly and a division of the University of Oxford, began testing that theory in 2019 by enrolling the first of 6,600 patients in a study known as EMPA-KIDNEY. Trial volunteers had kidney disease resulting from a wide variety of causes, including diabetes, and had both mild and severe symptoms. They were randomized to take either Jardiance or a placebo and followed to measure whether Jardiance could delay the need for dialysis, a kidney transplant or death from cardiovascular causes.

Lilly didn’t release specific results, stating it would outline them at an upcoming medical meeting. Physicians will closely examine the data when it’s available, particularly for evidence of how well Jardiance works in patients without diabetes.

If Jardiance is approved in kidney disease, it will follow AstraZeneca’s rival diabetes pill Farxiga, which the FDA cleared last April. A third drug in this class, Johnson & Johnson’s Invokana, is also marketed for prevention of kidney failure, but only in type 2 diabetics.

Although Jardiance isn’t yet authorized to treat as many diseases as Farxiga, it is still the biggest-selling drug in the class. Lilly recorded $1.5 billion in Jardiance revenue and Boehringer 2.5 billion euros ($2.7 billion) in 2021, compared with a total of $3 billion for Farxiga and $563 million for Invokana over the same time period.