Whether it’s a case of the stars aligning or elements combining, there are plenty of phrases to summarise the power that is unleashed when separate forces unite in a single, shared purpose. These moments of confluence are fertile territory for creativity and innovation. Indeed, as Steve Jobs said, it’s when you connect the dots together that you can “synthesize new things”. Gemma Budd and Irene Rossi at Nanopharm, discuss the reasons why both biologics and nasal delivery are continuing to attract attention. In particular, we will look at the demand for prophylactic therapies to protect populations against the ongoing threat from SARS-CoV-2, and the benefits of targeting these therapies locally in the nasal cavity.