A recent paper has shown that macromolecules can pass rapidly from the nose into the brain along olfactory nerves, and into the brain and brain stem along branches of the first and second trigeminal nerve structures, without any involvement of the cerebrospinal fluid (CSF) which was previously thought to be important. In animals, transport along the olfactory and trigeminal nerves has been shown to occur within minutes through channels created by ensheathing cells, rather than simply by slow axonal transport or diffusion. In this article, Aditya Das from Recipharm explores the drug candidates with the best potential for nasal delivery.

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