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Mastering ADC Bioconjugation: From DAR Control to Efficient Free Payload Removal

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Biopharma Group – 19th March 2025

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The Sweet Threat

DNA, RNA and proteins are not the only ways for living organisms to encode information and to communicate. Glycoconjugates and their cognate receptors, the C-type lectins, mediate and
tune the vast majority of the biological phenomena such as cell-cell adhesion, cell proliferation or pathogen detection. The pathogens developed through evolution glycan motifs enable
them to shape to some extent the immune response, in order to build a favourable niche for their development. Alexiane Decout, a Postdoctoral Scientist at EPFL, argues that more efforts are required to decipher these interactions and translate them to new therapies.

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