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The Importance of Testing for Pyrogens in Raw and In-process Materials

Pyrogens are substances that can induce shock, fever or death, with the most common type of pyrogen being the gram-negative bacteria derived Lipopolysaccharide or endotoxin. Due to the effect pyrogens can have on the body, testing for them is compulsory within the pharmaceutical and medical device industries. Sophie Bell at Wickham Laboratories Ltd explains why pyrogen testing is required for pharmaceuticals and medical devices that come into contact with blood, cerebral spinal fluid or internal body liquor.

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