There has been an unprecedented shift in global demographics, as the human population becomes more aged. This is bringing with it a significant burden of age-related disease and a requirement to better understand and
mitigate a dysregulated ageing process underpinning a wide range of non-communicable diseases. This review by Paul Shiels, Professor of Geroscience at the University of Glasgow et al. will explore these concepts in the context of emerging senotherapies and address the impact of potential confounding factors for their translation into clinical and general use.