Automated platforms based on picodroplet microfluidic technologies are one of the most promising tools for improving drug discovery efficiency. By encapsulating single cells in miniaturised, aqueous picolitre compartments, called picodroplets, these technologies provide a high-throughput and sensitive method to identify high-affinity, high-potency drug candidates with better biotherapeutic profiles and faster
developability timelines. Olivia Hughes at Sphere Fluidics determines how automated, picodroplet-based workflows can help to streamline the drug discovery process, increase throughput, and reduce time and operational costs.