Extended Range of Process-Scale Columns Prepacked with CEX, AEX, CEX-HIC, and AEX-HIC Chromatography Resins Provides an Effective Solution for Purification of Biomolecules in Downstream Processing
Bio-Rad Laboratories, Inc., a global leader in life science research and clinical diagnostics products, today announced the launch of prepacked process-scale Foresight™ Pro chromatography columns packed with Bio-Rad’s scalable Nuvia™ chromatography resins, for downstream process-scale chromatography applications throughout the various stages in biological drug development and manufacturing.
The extended range includes columns packed with anion exchangers (AEX) Nuvia Q Media and Nuvia HP-Q Media, cation exchanger (CEX) Nuvia HR-S Media and mixed-mode (MM) resins Nuvia cPrime Media, a CEX-hydrophobic interaction chromatography (CEX-HIC) resin, and Nuvia aPrime 4A Media, an AEX-HIC chromatography resin. These options expand the existing family of Foresight Pro columns packed with CHT™ Ceramic Hydroxyapatite Media Type I, Type II, and XT, which have been incorporated into various regulatory-approved processes worldwide. Columns prepacked with Nuvia resins are now available with internal diameters (ID) of 5 to 13 cm and bed heights of 10 and 20 cm. Columns with IDs of 20 to 45 cm are also in development with anticipated availability in early 2027.
Nuvia chromatography resins use Bio-Rad’s Nuvia bead technology, featuring a polyacrylamide (acrylamide polymer) base bead suitable for laboratory-scale purification, process development, pilot-scale production, and commercial biomanufacturing applications. Bio-Rad’s Nuvia resins are designed to have minimal non-specific binding reactions, due to the hydrophilic nature of the bead polymer and maintain a constant dynamic binding capacity over a wide range of flow rates. The Nuvia bead allows for fast mass transfer and is chemically and mechanically stable over a wide range of conditions. All Bio-Rad Foresight Pro Columns are manufactured in a controlled ISO Class 7 cleanroom, providing good manufacturing practice (GMP) ready columns. The prepacked columns’ standardised design and format can provide a more cost-effective and flexible solution than customer-packed columns, and columns are available in a range of diameters and bed volumes.
“The new Nuvia prepacked Foresight Pro chromatography columns build on the strong market response to our original CHT Ceramic Hydroxyapatite Media columns, which launched in 2022,” said Diab Elmashni, Director, Process Chromatography Business at Bio-Rad Laboratories. “Customers asked us for column options built around different resins and this line is our response. What sets these columns apart is that each one is packed using media from a single production lot, instead of blending multiple resin batches together during packing. That single-lot approach is what makes our Foresight Pro Columns a genuinely unique, single-source offering, providing biopharma customers with superior technical, application, and product support.”
Visit bio-rad.com/ForesightProColumns for more information.
