The rapidly growing field of cell and gene therapy is both exciting and confusing to many, including those who work in the medical community and on the periphery. Advancements of therapies happen at a feverish pace. The number of clinical trials increases exponentially in a short time and bringing therapies to commercialisation remains a hurdle. Vince Paolizzi at Pelican Bio analyses the intricacies and future considerations for the cell and gene therapy cold chain.