Investigators continually seek to improve the reproducibility of their results and the translatability of their preclinical work, while recognising that both goals pose challenges. In a 2016 Nature survey, over 70% of researchers said they were unable to reproduce another scientist’s study and over 50% had failed to reproduce their own studies. For evidence that translatability from the lab to the clinic remains problematic, one needs to look no further than the fact that nine out of 10 drug candidates fail at the clinical trial stage. Dr Alexander Maue at Taconic reveals how investigators can move beyond these obstacles and improve research outcomes.

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